One thing I noted is that even with Takedown in play, the Chairman’s Operative was still able to pull out underbosses. Would Mistbound, which directly references the deck, stop the Operative?
It would not. Any text that says put into play will always bypass not being able to play cards. An example of wording you can compare is Atlantean Font of Power which Mistbound would prevent that card play versus Slamara in Enclave of the Endlings which Mistbound would not prevent.
Use the same team but GrandPa Legacy instead of regular, then have GrandPa Gung-Ho Omnitron-X so they can get Take down in play and play/trash a single card from The Dreamer's deck in a round. Should be easy to take out a single Projection each round.
That makes for a long game especially if you ended up at five heroes if you play it out. Though thinking about it setting up a team which shuts down the villain deck every round is going to make for a long game as it means your damage output it likely low.
Not necessarily – I ended up with all of Omnitron-X's damaging Components out while I was waiting for Take Down and Mental Divergence to be drawn (somehow, whenever I want to test a set-up like this, the cards I need for it end up in the bottom half of the deck), and Visionary can get Demoralization out.
(I actually ended up Self-Sabotaging the damaging components away because it was starting to look like Voss was going to get taken out before I managed to get the set-up going.)
If Legacy gets his ring out (or you're using Young Legacy), he can also maintain a damage presence pretty reliably – and, since you've got the villain deck locked down, minions are a non-issue.
While the set-up depends on Legacy, it can be any Legacy (so Young Legacy can start and keep blasting, for instance) and it won't interrupt or stall his play-power-draw, and the other two can be whoever you want. With the villain deck locked down, you could easily round out the team with pure damage dealers like Ra or Haka.
Instead of Legacy preventing card plays, you could use Mister Fixer and the Grease Gun to prevent damage. That could be effective against the Dreamer.
The build may not rely on a particular Legacy, but Grandpa Legacy with Omnitron-X makes the setup achievable faster.
The Treacherous Ape can get around a Grease Gun.
No it doesn't. Treacherous Ape is the one dealing the damage.
It is, but possibly the reference being made was that the Ape destroys equipment when he's destroyed? In which case all you'd need would be for one other piece of equipment to be out, and then destroy that instead :).
That's the main problem with trying to set up a deck with the sole aim of "permablocking" a villain's deck. Some of the nastiest villains (Dawn, Chairman, M atriarch) have abilities or powers that allow them to search their deck/trash for cards, then "put those cards into play." Then all the Mistbounds/Take Downs in the world can't help you. :(
( Mind you, to me "put a card into play" still seems awfully close to "play a card," but I have come to accept that it's different. Maybe in V.2 of the game, change the "put into play" wording to something that doesn't use the word "play," so it's less confusing?)