I think that was me - feel free to swipe the observation, Dandolo!
Great guide. I was lucky enough to discover the sustained Sweetspot build in my first (blind!) play with her, and I loved the heck out of that. I figured out coupling it with Time’s Lessons placing Harnessed Anomaly under her top card every turn before her draw phase, making that one of the one-shots played.
I’m looking forward to my next play with La Comodora, to try and get some of the other combos you describe to work. Thanks for detailing them. That Magnifica Gambit looks… Amazing.