Here’s my Fanatic strategy:
She has lots of little one-shots that also allow her to draw a card. Play those ASAP. Sure, use Holy Nova and Final Dive situationally (such as when there are large groups of opponents, or when there is a single target hanging out with 4 HP. Especially use Final Dive on a Gene-Bound Guard - no reducing damage for you!), but the main things you want to get to fast are “Absolution”, Embolden, and Sacrosanct Martyr. Are you getting a plus 1 to all your damage, from Legacy, Ra, [redacted], or even maybe an Obsidian Field? Sweet! That makes Sacrosanct Martyr even better, as you can deal yourself 6 damage to output 7!
Now, blow yourself up. Since you’ve had a focus on drawing cards, you can easily get to at least one Aegis of Resurrection. Don’t bother putting it into play until you’re under 10 HP, as if it goes out earlier, it might get destroyed by a Villain or Environment card. Oh, also, hang on to End of Days for terrible situations (like a handful of minions and two spaceships from Voss, a pile of Citizens including Anvil and Truth from Dawn, or all of the Underbosses from The Chairman). And keep any Consecrated Ground cards for popping the significant threats - it’s one of the stronger ongoing/environment destruction cards since it also deals damage.
But your key focus? You want to feel the burn! Sacrosanct Martyr will quickly get you at not the highest HP, which means you won’t be taking a TON of damage from the Villain or Environment. Once you’re the lowest HP, that’s a bit more of a threat, but still, not too much, and you want it at that point. “Absolution” gives you a +1 to HP, which you certainly want. Embolden lets you use 2 powers and hurts you for 2, both of which you want. Sometimes, it’s correct to put Embolden on a different hero, but usually it’s for you, between your strong innate power, “Absolution”'s power, and Sacrosanct Martyr’s power.
So! Now, you’ve been doing a TON of damage. You’ve been hitting a lot of targets, giving yourself and your teammates occasional healing, taking out massive groups of threats with End of Days and individual hard to deal with cards with Consecrated Ground. You’ve even tossed around some annoying targets with Final Dive and once in a while skip the bulk of your turn to draw up to full with Prayer of Desperation. Sure, you might go into Divine Focus mode for a turn or two, but usually, you’re better off hanging on to those cards. Even Chastise is handy for when an Electropulse Explosive or The Kraken shows up.
This strategy alone is SOLID. You don’t NEED HP - they are just another resource. However, this strategy is not even finished. There’s one more delicious piece: Wrathful Retribution. Even without that major beat-down of a card, you’re doing a great job. But when you turn it over and the villain has under 30 HP, that’s Game Over folks. You take yourself down as close to 1 HP as possible fearlessly, since your Aegis will give you a second chance if you overshoot. And then you deal damage like only a self-righteous avenging angel can.
So, in short, she’s a slow burn. She has lots to do along the way, but between all her “draw a card” cards and Prayer of Desperation, you CAN get to what you need.
Thoughts?