The physical version is a fun little game! Lots of interesting decisions to make! 
From the look of the physical game, I feel like a digital version is the way to go. I want to see a little more before I back, but for ten bucks, I can't see a reason not to. :)
The game is absolutely a blast to play. It very much has a rogue-like feel. It's accessible, but a more experienced player will know what to look for in terms of skills that combo well together, and can create some really amazing builds. And then you still get brutally murdered when you roll 1's against a Phantom.
I can't wait to see John and Jeremy playing this on Stream. Also looking forward to the dev streams!
It looks a lot like Elder Sign-ish style gameplay with D&D-style thematics, which is all the pitch I need really.
Yeah, I figure it's the card equivalent of a Roguelike computer game - never played the original Rogue (don't even know what it looks like), but I've spent many hours in a game called Caveblazers which is pretty fun and which I know is along those lines (similar to another game called Spelunky). Out of curiosity I just Googled for the physical game and it's out of stock at Games Lore and over a hundred quid(!?) on Amazon :O. So I'm guessing it's been around long enough to go out of print or something, because wow.
They recently completed a Kickstarter for an expansion and reprint.
Also note that some of the sets are printed on plastic cards, which are more expensive. That might be part of why that set was so much money. 
Hmm, looking at that link it appears I can still pre-order the game and/or expansion from there,a nd a little further digging on the Kickstarter's main page has turned up the shipping costs. A quick check of the Google currency converter shows that it would cost me over 40 quid for both the base game and expansion, plus shpping. Hm. Maybe I'll think about it - I'm not sure who I'd get to play it with, anyway.
Fanatic has been added as a stretch goal https://www.kickstarter.com/projects/handelabra/one-deck-dungeon-digital-tabletop-game/posts/2036496
And avatars!!! 
YAY!!!
We're almost funded - could you be the one to put us over the top? =)
…and now it’s funded!
Huzzah! Here's to at least 30k by the end! :D
And with the new update comes tablet support!