I decided to try out Spite as a villain in the iPad app and found the whoel thing an exercise in frustration.
What made it even more annoying was what seems to be a bug in the game. The PL602 Compound Omicron card states "The first time Spite would be dealt damage each turn, reduce that damage by H minus 2" (emphasis mine).
What was happening, though, was that all attacks were being reduced, not just the first one. So all the heroes had to do at least 4 points of damage to even register against Spite, only to see it be erased the next time he hits a hero.
Pretty much makes the villain unplayable, in my opinion.
Each hero, the villain, and the environment have a turn. Once each one had a turn, they complete a round. So, in Spite's case, the card would reduce the first damage each turn, not each round. Also, the number it increases with the number of heroes. This is a case where more heroes can make the game much harder, if you can't deal irrudicible damage.