I really enjoy playing Sky-scraper; I think she has a lot of interesting moves in her deck - yesterday I did two Colossal Left Hooks in a row followed by a Tectonic Chokeslam - and it can be fun to simply embrace her indiscriminate-ness sometimes. But as we've been playing, we've been tracking our wins and losses, and so far: Sky-scraper is the least reliable hero. We've got her record standing at just slightly more losses than wins, while the other heroes are solidly in the black.
I think it comes back to the fact that her deck is set up in such a way that if she can't play cards, she's hosed. Especially if she's Tiny, which is the natural early-phase strategy for her, because the Tiny power has her play cards. You might shrink in order to deploy a lot of Links, but then you're one Leaking Room or Traffic Pileup away from total impotence. Being Normal isn't much better.
The Naturalist and Mister Fixer have similar overall strategies, where they change their rules of engagement to fit the situation. But the Naturalist is far more flexible, since his power has him search and put a form into play. And Mister Fixer is more reliable, since his power always deals damage, and you go in knowing that that's what he does. On the one hand, I really like the thematic implications of Sky-scraper's deck - that she thinks of actions first, and the size change just comes as a consequence. And nothing beats doing a few Linking Incursions, then chaining a Colossal Left Hook with an Explosive Reveal. Aggression Modulators are fantastic, and I'd rather have a Thorathian Monolith on my side than not. But in the end, it just doesn't pay off.
I'm wondering what all your experience has been with her.