I had one awesome fight, with Haka, ExPat, Ra, and someone else (I don't remember exactly, but their incap let them destroy environment cards, I think; this was before Infernal Relics, I think) VS. Plague Rat in Insula Primalis. At a certain point in the game, Plague Rat was still at 65 HP, Haka was down to 1, and everyone else was incapped. I still won.
As it turns out, Mere + 3 dominions + 2 extra powers per round + a free environment destruction each round is a pretty good way to build up your hand size. It turned into what I imagined to be a down-to-the-wire, no-holds-barred beatdown between Haka and Plague Rat. No one else there (conscious, anyway), nothing getting in the way; just an extremely pissed off Maori in Barbarian Rage mode and a giant rat man beating the crap out of each other. Each round it went something like:
Plage rat plays a card, deals damage. Deals a little more damage at end of turn.
Ra's turn: Haka punches Plague Rat. Draw a card.
Expat's turn: Haka punches Plague Rat. Draw a card.
???'s turn: destroy an environment card. Draw 3 cards.
Haka's turn: play elbow smash, rampage, or Haka of Restoration; punch Plague Rat; draw a card. draw a card.
Environment happens. Not very relevant.
Repeat.
It was an awesome turnaround, and still one of my favorite victories.
Oh, and then there was one game where Dawn played "Channel The Eclipse" with her damage buffed by 3. While she had 5 HP.
"Will my powers kill me? Certainly. But they will surely kill YOU fir-" DED.