If Guise high-fives Omnitron-X with Reactive Plating Subroutine in play, and Guise takes damage that Omnitron-X reduces with a Plating card, Guise will react. Guise doesn’t even need to use Lemme See That on the plating, which means he’ll react to instances of 1 or 2 damage! Works great on the Ennead’s Elemental Storm.
Omnitron-U is also a fun partner for Guise, because Guise can copy its base power and then throw out a ton of Ongoing cards just to get the damage when they disappear.
Never tried this one, but it occurred to me that if playing The Sentinels against Progeny, if you could pull out Caliginous Form and bring Writhe below 10 HP, you could lock Progeny into a loop where he flips (which might be particularly useful in Advanced Mode), keeps hitting himself at the beginning of his own turn, and spares the other heroes.
...of course, if you *don't* get lucky enough to pull Caliginous Form, then The Sentinels likely will ALL serve as punching bags to spare the rest of the heroes.
Progeny typically does multiple instances of damage so you'd need to combo it with Human Shield or something else that would ensure the end of turn damage by Progeny is the first hit made on Writhe.
Setback's "Whoops! Sorry!" doesn't specify that you have to destroy an ongoing or equipment card, you can destroy any non-character card belonging to another hero. This includes, for instance, Bee Bot, which means you get to destroy two troublesome ongoing or environment cards and do some damage to boot.
(I also just noticed on the art of that card that the Bunker suit itself seems to be sighing in exasperation.)
Well, one "unexpected combination" that I experienced recently, that turned out to be very BAD was End of Days and The Dreamer. I had already flipped her, and had about half the cards that I needed, and the game was going very poorly (everyone in single digit hp, 1 incapacitated I think). I thought I would sneak a win by using End of Days to clear the board and win. However, as End of Days began to process, I realized my mistake. It cleared all the projections (yay!) but then began destroying the cards under her as well. Seeing as these were no longer "projections" (just villain cards) they did not immediately re-deposit back under her, and merely went to the trash. In the end, I just swapped a little over half the cards I needed for a little under half the cards I needed :( I feel confident this is one that I would have played incorrectly at the table.
Yeah, I've done the End of Days Dreamer panic as well. In my case, I was fortunate enough to have an Illusionary Demon out, so I could use Powerhound's trick.
On the other hand, End of Days is just brilliant for flipping the Dreamer in the first place. No muss, no fuss.
Another, simpler one for Mr. Fixer I was playing around with earlier -- Compulsion Cannister + Driving Mantis. So long as he has no buffs out, he can redirect the first shot.
So I'm not sure if this is a combination because it only involves one deck, but the game made me realize that Sentinels Tactics triggers immediately after the first instance of damage, with other checks and results happening afterward.
For instance, I killed Ambuscade with Fling into Darkness from 10 HP. Mainstay did the first hit (4 with a buff from his chains), then ST triggered so the Idealist could smack him for another 2, putting him under the 4 HP threshold.