Villains of the Multiverse Nemesis List

Ambuscade - The Naturalist, Professor Pollution, and Equity.

  • Desert Eagle - Haka and The Hippo.
  • Glamour - Tachyon, Friction, and Miss Information.
  • Magman - Unity and The Radioactivist.
  • Ray-Manta - Omnitron-X, Omni-Blade, Partial Omni-Drone.
  • Revolt - Setback, Plague Rat, Heartbreaker, and Revenant.

Biomancer - The Scholar and Hermetic.

Bugbear - NightMist, Heartbreaker and Man-Grove.

  • Quetzalcoatl - Dr. Medico, Mainstay, The Idealist, Writhe, Judge Mental and Crackjaw Crew 
  • Ammut - Ra, Calypso, and Anubis.
  • Cueball - Guise, Green Grosser, and Argentium

Citizen Hammer - The Visionary, Citizen Anvil, and Major Flay.

Citizen Anvil - The Visionary, Citizen Hammer, and Major Flay.

Greazer - Any Hero

  • Galactra - Captain Cosmic and Empyreon.
  • Rahazar - Parse and Highbrow.

La Capitan - Chrono-Ranger, Doc Tusser, and Rat Beast.

Miss Information - FF, VV, Glamour, and "Barber" Overbrook.

  • Balarian - Argent Adept, Captain Cosmic, Haka, Tempest, Fanatic, Galactra, Desert Eagle, The Idolator, Blood Countess Bathory, Ruin, The Seer, Empyreon, The Hippo, and Vyktor. 
  • Heartbreaker - Mister Fixer, Setback, NightMist, Expatriette, Bugbear, Plague Rat, Revolt, The Operative, Zhu Long, Citizen Slash, Man-Grove, Revenant, and The True Form.
  • Judge Mental - Dr. Medico, Mainstay, The Idealist, Writhe, Quetzalcoatl, and Crackjaw Crew .
  • Green Grosser - Guise, Cueball, and Argentium.

Plague Rat - Setback, Revenant, and Revolt.

Sergeant Steel - KNYFE and Choke.

The Operative - Mister Fixer, Zhu Long, and The True Form.

  • Mayor Overbrook - The Wraith, Ermine, and Miss Information.
  • Professor Pollution - The Naturalist, Ambuscade, and Equity.
  • The Idolator - Fanatic, Blood Countess Bathory, and The Seer.

While you're at it, do you have the difficulty ratings for them?

Difficulty ratings:

Ambuscade - 2

Biomancer - 3

Bugbear - 3

Citizen Hammer & Hammer - 3

Greazer - 2

La Capitan - 2

Miss Information - 1

The Operative - 1

Plague Rat - 2

Sergeant Steel - 3

Miss Information - 1

The Operative - 1

Huh, that's a little disappointing.  I was hoping The Operative would be a 3 or 4 star, but I'll always take some easier difficulty Vengeance villains since I've always found V5 to be really hard.

 

What makes these two so easy, assuming you've played with them?

The Operative is mostly dealing damage and has no way to protect herself from damage. Of the three targets in her deck, only one of them actually does damage. This means if you stop The Operative from dealing damage then she will not be doing much. 

Miss Information is hard to say, as I don't have much experience with it. Though she does have several cards that not only hurt heroes, but can also help. Such as Judge Mental increases all Psychic damage by 2, so if you have a hero that is dealing Psychic damage then it will be pretty handy. Unless The Sentinels are in play, which Judge Mental then also prevents Hero damage from being increased. Another makes it so Heroes cannot use powers, but at the end of their turn that may play a card. Also, I think most (if not all) her Ongoings have an alternate means of destruction.

So I take it that having other villains as a nemesis is in the setup text for the villain or card text for those that are part of a deck? 

They just have a Nemesis Icon. An example being that The Naturalist, Ambuscade, Professor Pollution, and Equity all of The Naturalist's nemesis icon. So if Professor Pollution deals damage to Mister Fixer, but thanks to Driving Mantis it is redirected to Ambuscade, it will be increased.

Ok.  I guess I had a brainfart on who had which nemesis icons.