Apologies if this has been covered somewhere already …
If The Wraith has Combat Stance (The first time The Wraith is dealt damage by a target each turn, The Wraith deals that target 2 melee damage) and an Electro-Pulse Explosive (At the start of the villain turn, this card deals each hero target X lightning damage, where x = the current HP of this card) goes off, can the players choose to target The Wraith first such that Combat Stance would cause the Electro-pulse explosive to lose HP before the other heroes were targeted by it, thus doing the other heroes less damage?