I discarded multiple copies of each mode card, but specifically discarded 1 of each type for the civilians.
I used the full F5 (base versions).
Here is how to consistently win against Progeny.
START
Make sure Wraith starts with an eyepiece or an impromptu invention.
Make sure AZ starts with a null-point, so he can help tank
If you don’t start with these things, reset.
EARLY GAME
If Legacy starts with any other powers, great. You want to get to a point where he can make himself immune to energy damage and redirect it to protect the others.
Prioritize Wraith getting dual eyepieces, so that you have greater deck control. It also raises the chance she will get a throat jab.
Once Wraith has a Throat Jab, KO Tachyon. Her ability to put cards from trash to hand makes sure that you can throat jab every round.
If the environment plays Rooftop Combat, keep it in play until you are fully set up. Hypersonics/Throat jab as needed. If not, you WILL hit one of those turns where the environment and Progeny combine to lock you out of doing anything for multiple rounds. It sucks, which is why I prioritize eyepieces and next evolution/lead from the front, so I have a better chance of avoiding it/surviving it.
MID GAME
If Progeny or the Environment card locks you before you have the setup to rank indefinitely, you need to make a judgement call and reset or try and take the hit. If I have the stuff in hand to get the immunity/damage prevention combo, then I’ll usually take the hit.
My Legacy turns often consist of making myself immune to Energy damage, then motivationally punching AZ. He then heals on his turn.
If Progeny resets you too much with an unexpected Beginning of the End, reset. I try and avoid this with dual eyepieces and liberal use of the rewind button, but it can happen.
LATE GAME
Remember that “the inevitable” discards anything that it reveals that isn’t an ongoing, and “form of the harbinger” discards anything it reveals that isn’t a Scion card. This is a great way of getting rid of clumps of stuff that you’ve been shoving to the bottom of the deck via eyepiece.