Just thought I'd share some funny/cool things that have happened in games I've had. Personally I think it's just epic when a certain combination of cards happens to come out which results in you being able to uterly destroy the villain or otherwise make them ineffective, however difficult they might usually be to defeat >:). Here are a few things I can think of that we've had happen in our games…
Matriarch in the Final Wasteland. We deliberately played this set-up to see if we could get all her stuff removed from the game. First environment card to come out was a Horrid Skunk Ape. Second card was Unforgiving Wasteland. I don't think we could possibly have had a better result than that. To make things even better, I think the next card was the Library, followed by Con's Bunker. I think another creature or two may have come out after that, but the game didn't go on too much longer. End result - every one of Lilian's targets apart from one single Carrion Field (which we had destroyed ourselves) got removed by the environment, so we never took Fowl-destruction damage and the Matriarch couldn't benefit in any way from her cohorts (or the Mask) once they went down too. Suffice to say, she wasn't much of a hassle to take down at that point ;).
Haka eating Ambuscade's Cloaking Device with Savage Mana. I think this has happened a couple of times now. It means that if Ambuscade subsequently plays a copy of Vanish, he's basically wasted his turn as it does absolutely nothing (except to shuffle his deck, I suppose, if any manipulation had affected it prioer to that point).
Legacy, Ra, and anyone versus Akash'Bhuta in Insula Primalis. We do this on occasion when we fancy a bit of an easy, fun game. Flesh of the Sun God plus the volcano means that while Ra spends his Power phase for the remainder of the game not being able to nuke anything (unless he has a Flame Spike handy), we all get to sit back and laugh at Akash'Bhuta as the volcano repeatedly nukes her…for buffed damage, if Imbued Fire is out, and even more so if Chrono Ranger happens to be present and has put By Any Means on her.
Another Akash'Bhuta one. I'm sure plenty of people have done this - End of Days versus a large number of limbs. At the time we did this, Akash'Bhuta had By Any Means on her, which we conveniently decided to destroy after Akash'Bhuta had taken buffed damage for all her limbs being destroyed. I think the damage total was 103, which brought her down to about 42hp or so.
Apostate in the Realm of Discord. The environment put out Imbued Vitality and I jokingly suggested that it would be funny if Apostate were to then play an Apocalypse, so we could batter it to "death". And then guess what he played…even better was that the Imbued Vitality went away a round or two later, so he never had a chance to destroy our stuff the same way :).
Deciding to try Timeshifting Gloomy to see if his last relic would come up (the other two were already destroyed, I think) in order to chuck it straight onto the trash pile, and having it actually work first time so that Gloomy automatically lost the moment his next turn started :D.
Playing as the Adept, and dealing a grand total of one single point of damage for the entire fight (might have been two…I can't remember whether we were fighting Gloomy or Akash'Bhuta), just because it was all we needed to finish off the villain :).
Double Stun Bolts versus Spite, with Smoke Bombs and a highest-hp hero with soak for the occasions when he might manage to do enough damage to actually hit anyone. The other day we had TLT, Wraith, and Haka taking him down. Wraith never took a hit the whole fight, TLT did once or twice which put her on 26hp so was tied for lowest with Wraith. Haka got hit a few times early on but still had more hp than the other two, plus he played a few healing cards putting back to full, or close to it. And he got his Ta Moko out early. It only took about four turns or so for Spite to get out all his drugs, but we didn't really mind because by then I had my Stun Bolts out and he failed to do us any damage whatsoever for the remainder of the game. Mind you, I think this is one of those things that most people have done at some point.
Same for Meteor Storm versus Plauge Rat, taking the time to get perfectly set up before you destroy it.
And also Mr Fixer wielding his Jack Handle against Rat, at which point you want him to become Infected :).
Yet another Rat set-up is Omni-10, with his Ablative Coating and Reactive Plating Subroutine in play ASAP, which I managed to do at one point. I think I started the game with the Coating in-hand and then had the RPS come out in that turn's Draw phase, or very soon afterwards. I expect I later got out an Innervation Ray or two to counter the damage I was taking. It was fun to constantly plink Rat in exchange for all the plink damage he was dealing me :D.
I had a really cool idea a few days ago, and we tried it the other day but unfortunately I didn't get the cards I needed until we were all nearly dead and ended up losing. It's basically a set-up which relies on a very specific combination of cards in a certain situation, but I just think it'll be really funny if I can ever pull it off. Needs the Visionary versus Voss, with the other heroes preferably being those who can either deal high damage or have irreducible damage, and none who rely on being able to hit everything at once. Wait for a Gene-Bound Psy-Weaver to come out. Play Wrest the Mind and preferably also Twist the Ether on it (to change its damage totals, not so much the type). Then play TK Cocoon.
Anyone else got any amusing stories or cool ideas or anything?