I fell in love with Setback the other day and read your guide to see what else I could do. I haven’t played him as a tank yet, so seeing those combos was nice.
A couple you missed.
Silver lining, looking up and high risk behavior x2. You get massive token generation and massive damage. When you get to that point where you are going to die, you play cause and effect and come back with great health and no tokens for the villain to hit you with, after dealing crazy damage.
Setback loves visionary. Twist the ether reduces his self damage while boosting his other damage, something he loves. And mental divergence is amazing with dps setback. Getting to risk silver lining back twice makes setback a happy camper. And all her manipulation cards allows him to judge when to go all out or when to spend his tokens.