Six Player Game?

I heard talk at one point about a variant way to play the game with six players. Any thoughts … ?

IIRC, the designer said, “play 2 tables of 3 heroes games, there’s enough heroes and villains to go around” to that effect.

The original set villains tend to get to the point of rediculously simple when you have more than 5 heroes. Also, it breaks the game against Plague Rat as he can only infect a maximum of 5 heroes, thus never allowing the condition of infecting all heroes.