Skyscraper also has a Tiny card that returns all of her links to her hand, and then lets her replay as many links or tiny cards as she returned, so you can reattach and reapply damage and debuffs as needed. Her card that reduces damage an Environment targets deals to heroes and increase the damage it deals to villains is situational, but it is a significant advantage when there are AoE Environment targets to exploit.
She has obvious synergy with Unity, who can blow up her damage links and then Skyscraper can just recycle them with her Tiny form power.
Her only weird spot, to me, is her flow and synergy. She's all about timing and being able to switch when needed to suit the team. She's very versatile, but using her to her best capacity isn't the easiest all the time -- figuring out what your team needs and what you have available is especially critical with her. She is great for spot tanking, for example, but can't do it consistently as Legacy, at least without help from, say, Argent Adept to recover, draw, and play Thorian Monolith. Unless you need to play a card to change form or use a power from another form, dropping links and collecting 3 cards per turn in her normal-sized form is a good way to build a hand that will give you many options.
Speaking of which, like many heroes, Skycraper loves AA, but it's amazing in her Large form. Buffing her damage reduction to 3 while Thorian Monolith is in play generally means she can go to town with her cards and power that damage heroes without worry even if Legacy or other damage buffs are in play, and AA can let her play the 4 damage to 1 target, 1 damage to every target card while Thorian Monolith is out and recycle Thorian Monolith.
Any hero that needs equipment to get going -- Nightmist, AZ (and he can search out his +1 cold damage equipment, which he can't do natively), AA, Expatriate, Bunker, Wraith, Omnitron X, etc. will love her link that gives someone the power to discard a card to put an equipment card into play or into their hand, particularly heroes with recurring card draw, such as Wraith and Bunker. Even if someone who can use it but doesn't need it as much (Tachyon w/o goggles, Ra w/o staff fetching, Legacy w/o a ring, Tempest, Haka, Unity, for her equipment that lets her discard cards to play golems), can still use it, and you can redeploy it later.
Speaking of Nightmist, she loves Thorian Monolith, just don't abuse the damage-redirection by shifting too much to Skyscraper ;) Az needs to be careful that he doesn't fry Skyscraper while it's active, however, which makes the Freedom Six AZ a better combo with her if you expect her to tank, due to the reliable, non-self harming damage.