Ambuscade, Fright Train, Friction, Plague Rat, and Baron Blade against The Wraith, Setback, Fugue State Parse, Expatriette, and Omnitron-X, fighting in the Celestial Tribunal. It's a Revocorp Brawl.
Randomized.
Aieeeeeeeee!
I lost count of how many times this game went absolutely sideways for me. And of course, with randomization, tips are of minimal use. But here's what I found:
Ablative Coating and Smoke Bombs (if you can get Omnitron-X to be the highest-HP character) are a great way to tank. The vast majority of the damage is melee, projectile, or toxic.
Nemeses to avoid/remove at all costs: Glamour (as always), Highbrow, Revenant. Many of the others (The Hippo, Choke, Ray Manta, Omni-Blade) are certainly annoying, but not nearly as devastating.
Never let the system choose targeting order. Especially if you can arrange things so that you neutralize much of Plague Rat's all-targets attacks on your heroes, then the Rat offs the last Handler and goes on a rampage through the villains.
For Expatriette, a shotgun is a girl's best friend.
Device to get rid of: Impulsion Beam. The rest are dealwithable.
Setback is going to get hurt a lot this game, as it seems half the cards have his nemesis icon. Silver Lining can be very useful. Cause and Effect can at least make the damage work for you, too.
Let the heroes do a lot of the work for you. Many of them attack themselves or each other; try to make those count. (Shock Dampeners should go quickly.)
Parse could do a fair amount of discarding this game, as usual, so get the Multipliers out.
I got a Fine with everyone standing and I'm just glad it's over.