Easy mint for me; I managed to get Friendly Fire, Mindbreaker, Indiscriminate and the healing Title onto Setback, Human Shield and Durasteel Chains onto Mainstay, and Chaos Lord onto Guise.
The result was that whenever any of my heroes did anything, they could poke Setback for 2, at which point he would heal for 1 and attack all heroes and villains for 2, and then Mainstay would absorb all of the damage harmlessly except for a poke at Guise, who would then play a free card. The Sentinels kept healing Setback and Guise up, and I overwhelmed Kaargra with incredible speed.