Interesting, and not a team I would normally go to, but I think it's worth a shot. If you were to take one out for a 4 person game, who would it be? Friday I'll try it with my group of friends and see how it turns out. We'll probably start with normal mode to see if we can get the hang of it.
There was an event when Wrath of the Comsos just came out, where you pick your "best" team to go up against four unknown villains. I thing I noticed was that even though each team was different, there wasn't a drastic score difference between any of them (if they submitted a game).
Interesting, all of my teams are hefty on the control with high burst damage, but it seems like a lot of the other ones seem more damage focused with little control. Is there a plan to do this again? I would be curious to see if the results change on all advanced, or half games at advanced? Some of those Villains I don't own yet unfortunately though, so we can't even playtest against that 
I would drop both Expatriette and Absolute Zero and add Setback. Since his damage is on par with Absolute Zero and Expatriette, still able to drestroy Ongoing cards, and can supply some healing and cards to the team when needed.
I'll let you know how it goes. Three of the four my friends play on occasion, so we shouldn't have much trouble getting into a groove there except with DW Nightmist and K:AA since the powers are different than normal. We'll probably give Mr. Fixer to the guy who normally plays wraith since they are…somewhat similar in the sense they both use Equipment ;).
It might be done again, but it might have to be slightly different. The event was purposely based around the release of new villains that you have never played against. There were also some other events, but each had some slight rule tweek that made it not just straight "best hero team". See The Depth Chart Event.
Also, remember that people have very different play styles. It's not just about what each hero is good at, but what they are good at when being played by a particular player. Many people will play the same hero differently based on the things that they think are most valuable (or fun). Haka can dish out tons of damage, but he can also be a very effective tank. He can also be a terrible damage dealer and tank all at once - it depends on how you play him.
For the same reason, Mr. Fixer might be fantastic at tanking when Ronway plays him, but terrible at it when I play him, because we make different choices. So, don't take the statement "Hero X is good at Y" to mean that Hero X is always good at Y regardless of who is playing them. You might have to experiment for a while before you figure out how you can be most effective with a hero.
My 4 hero team:
Expat
Sky-Scraper
Wraith
Mr. Fixer
They have everything you could want except card play prevention and the Micro-Assembler makes this team insane.
For a 5th I add DW Nightmist.
Just for fun 5 player team:
Tempest
Argent Adept
Nightmist
Bunker
Scholar
Because after a bit of deck burning neither the villain nor the Environment will ever play cards again.
I'm going to be boring and say the Freedom Five is my go-to team, with whom I rarely, if ever, lose. And I try to do them in order of when they're recruited according to the comic, because I'm a dork.
Legacy -- self explanatory. Up to +2 to all damage, protection, extra cards...honestly, he's the one I leave out when I want a challenge.
Bunker -- he's my main damage dealer, goal is usually to get Flak Cannon or Grenade Launcher out along with the Omnicannon, though occasionally I'll focus him on tanking and healing. I love him in minion-heavy decks. A couple rounds against Voss with Ammo Drop out and I've got damn near his whole deck in my hand.
Tachyon -- she pairs extremely well with Legacy, who turns all her 1-damage cards into serious damage, and having her keep the villain from doing damage for a round is invaluable. She also ends up being another nuker toward the end, though I'll occasionally use Lightspeed Barrage as quick problem solving.
Wraith -- she mainly finds use as deck control -- having one or two Eyepieces out makes most villains outright trivial. Sometimes I'll use her damaging powers (with Legacy buffing everyone +2 and her computer? Scary.), but I find a lot more use for her as a problem solver than a damage dealer.
Absolute Zero -- He benefits the most out of Legacy's buffs, and I can regularly get hugely powerful turns out of him. Plus his ability to heal (again, hugely boosted by Legacy's buffs) makes him as good a tank as anyone despite his lack of armor. He's also amazing for Ongoing destruction.
Sometimes I'll switch out AZ for Unity -- with all her potential instances of damage (plus Champion Bot) she can be insane on a team with Legacy's buffs. If I can keep her bots out for more than a round or two, that usually spells the end of a villain.
I'm really waiting for the IR expansion in the app, though, so I can start playing around with Argent Adept and Nightmist. I've played with them a couple times in the physical game, and I'm itching for a chance to really experiment. Once they do, my go-to team might change.
My strongest team:
1. Legacy (non-promo)
2. Team Leader Tachyon
3. Omnitron-X
4. Tempest
5. Parse
Remove the highest numbers for lower hero count games. Legacy, Tempest, and Omnitron-X provide team heals and some tanking. Legacy provides a damage boost. Tachyon provides card plays. Omnitron-X starts out by having Legacy play or discard the top card of his deck. This gets Legacy tanky fast. Tempest provides AoE damage. Parse is the controller that makes everyone easy to fight.
My favorite team:
1. Argent Adept (for the most fun, take the Prime Warden one)
2. The Scholar (non-promo)
3. Setback (non-promo)
4. Team Leader Tachyon
5. Anyone you want. Some prime ones are AZ, Parse, Omnitron-X, Legacy, and Tempest.
This team is about lots of plays and lots of heals. The Scholar goes for three Mortal Form to Energies and one or more Solid to Liquids. He tries to take as much damage as possible. Argent Adept goes for card plays, power uses, and healing. Setback gives The Scholar more cards (Surprising Fortune), heals everyone for 2 (Cash Out), and gives them all extra power uses (Turn of Events). Team Leader Tachyon feeds them the cards needed to keep this going. Allies you want should grant card plays, card draws, power uses, healing, or a way to damage The Scholar when he's fully healed to keep his heal/damage engine running.
Does the game change for your teams if you replace Parse with Dark or normal Visionary?
I don't have Dark Visionary, so I don't use her. Visionary herself doesn't have the consistency Parse gets for controlling the villain deck since her control abilities are one-shots, not ongoings. Dark Visionary might flip that and work alright in Parse's position.
The few times I played Parse I got (seemingly) terrible hands for the situation, so I haven't played her much. Add that to the list of people to play Friday!
I don't think I've ever chosen a team for a specific matchup, but if I were, it would likely be Nightmist, Redeemer Fanatic, PW Argent, Naturalist and really anyone in the 5th spot (Parse would be good). Essentially, you have 3 heroes who want to take damage/can seriously tank for AA who gets set up incredibly fast in this version and can generally get Emboldened, which pretty much wins you the game. If playing with Desperate Prey Naturalist, this team is even more insane
Nothing boring about that. The Freedom Five are solid.
It's always hard to turn down a game with the prime wardens. I have never played a game with them where everybody was below half of their maximum HP, they just work so well as a team. That plus I really enjoy playing Argent Adept, every game I played with him, I have become the best friend of a lot of heros
Who has been your hardest fight with the PW so far? Seems like a few people enjoy this team as well.
My hardest fight with the prime wardens was advanced challenge Infinitor. Extreme DR vs extreme healing in a slugfest to make the walls shake it took all of the prime wardens power combo abuse to wreck his day did not get to shorten the fight by triple wrathful retribution that time.
Wow. Last night was the first time I've ever killed someone with WR. In fact, I was so excited I had to take a screenshot of it. It was a tad overkill, but the only other time it had come up someone hit the villain for 1 and ended it before I could WR on them 
I'll just leave this here for posterity https://greaterthangames.com/forum/topic/episode-37-waiting-for-capt-cosmos-6287. Wasn't the full PW, but AA + Redeemer Fanatic led to 4 Wrathfuls in that game to help take out the Advanced Ennead