Spite has long been my least-favorite Villain. He isn't (necessarily) the *hardest*, but he's the least fun. He's for all practical purposes immune to damage until he flips, and he will have done a lot of damage to the heroes before that happens. The only viable general strategy seems to be to try and get as many Victims into the Safehouse as possible, then burn him down fast after he takes the hit from flipping.
Today, while beta testing the App, I found a new reason to hate Spite. When he flipped, with 8 Victims saved, he took no damage. I thought it was a bug at first, but then I realized the awful truth. Technically, it's not the Safehouse doing the damage, but Spite damaging *himself*, and I had hit him with a Throat Jab. Argh!!!!!